Get ABC Transporters and Multidrug Resistance (Wiley Series in PDF

By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

ISBN-10: 0470227346

ISBN-13: 9780470227343

A accomplished evaluate of the most up-tp-date medical study on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are identified to play a very important position within the improvement of multidrug resistance (MDR). MDR is the facility of pathologic cells, akin to tumors, to resist chemical compounds designed to focus on and smash such cells. In MDR, sufferers who're on medicine finally increase resistance not to purely the drug they're taking, yet to numerous sorts of drugs.ABC Transporters and Multidrug Resistance bargains a necessary source for pharmaceutical researchers who're operating to find medicinal drugs to counteract multidrug resistance in illnesses reminiscent of melanoma. in a single entire quantity, this booklet incorporates a selection of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.This finished quantity presents an summary at the description of the constitution, the genome, common tissue expression, physiological point, and mechanism of motion of the ABC protein. The specialist members discover the expression, detection, and implications of ABC proteins in hematological malignancies and stable tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. moreover, the e-book bargains crucial details at the organic and scientific point of multidrug resistance.

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Extra info for ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)

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Indeed, N-myc overexpression is frequently associated with the MDR phenotype and high expression of ABCB1 in neuroblastoma metastasic tumors. Epigenetic changes in histone H3 methylation induced by cytotoxic drug treatments have been shown to be responsible for the ABCB1 gene overexpression in cancer-resistant cells (42). 2. ABCB1 Gene Polymorphisms The expression level and function of ABCB1 gene also depends on some gene polymorphisms. During the last decade, several single-nucleotide polymorphisms (SNPs) have been identified in the coding region of the gene (15, 43).

Siegsmund M, Brinkmann U, Scháffeler E, Weirich G, Schwab M, Eichelbaum M et al. 2002. Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. J Am Soc Nephrol 13: 1847–1854. 47. Taniguchi S, Mochida Y, Uchiumi T, Tahira T, Hayashi K, Takagi K et al. 2003. Genetic polymorphism at the 5′ regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation of expression level in the colon. Mol Cancer Ther 2: 1351–1359.

64. Rosenberg MF, Callaghan R, Modok S, Higgins CF, and Ford RC. 2005. Threedimensional structure of P-glycoprotein: The transmembrane regions adopt an 40 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. THE P-GLYCOPROTEIN 170 asymmetric configuration in the nucleotide-bound state. J Biol Chem 280: 2857–2862. Vandevuer S, Van Bambeke F, Tulkens PM, and Prévost M. 2006. Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: Insight into the mechanism of ligand migration and binding sites.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development) by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

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